Xiufang Wang,
Zhaoqing Zhang 
For correspondence:- Zhaoqing Zhang Email: 187076605@qq.com
Received: 8 June 2014 Accepted: 18 August 2014 Published: 24 September 2014
Citation: Wang X, Zhang Z. A Study of the Association of Polymorphism rs5860110 and its Protective Role against Ankylosing Spondylitis in a Chinese Population. Trop J Pharm Res 2014; 13(9):1545-1548 doi: 10.4314/tjpr.v13i9.23
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate whether secreted phosphoprotein-1A288;SPP1A289; promoter variants are associated with susceptibility to ankylosing spondylitis (AS) in the western China.
Methods: The rs5860110 variant of SPP1 promoter was genotyped using direct sequencing in 120 unrelated AS patients and 106 ethnically matched healthy controls. All the patients were human leukocyte antigen A288;HLAA289;-B27 positive. Frequencies of different genotypes and alleles were analyzed among the AS patients and the controls.
Results: In AS patient group, frequency of +254 SPP1 promoter genotype was 0.483 in base TG/TG homozygotes and 0.517 in TG-(deletion)/TG-(deletion) homozygotes, while the values for the control group were 0.311 and 0.689, respectively. However, TG-(deletion)/TG heterozygote was not detected in this study. The rs5860110 single nucleotide polymorphism (SNP) in SPP1 was significantly different when all AS patients were compared to controls (p < 0.01).
Conclusion: The rs5860110 SNP in SPP1 has a protective role against AS in the selected Chinese population.
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