MA Momoh1 
,
MO Adedokun2,
SB Lawal3,
GO Ubochi1
For correspondence:- Momoh Email: jointmomoh@yahoo.com Tel:+2348037784357
Received: 2 February 2013 Accepted: 29 August 2014 Published: 19 October 2014
Citation: Momoh M, Adedokun M, Lawal S, Ubochi G. Formulation and In vitro Evaluation of Ibuprofen-Loaded Poly(D,L-lactide-co-glycolide) Microparticles. Trop J Pharm Res 2014; 13(10):1571-1576 doi: 10.4314/tjpr.v13i10.1
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To enhance and control the release of ibuprofen from poly(D,L-lactide-co-glycolide) (PLGA) microparticles.
Methods: Ibuprofen-loaded microparticles containing PLGA were formulated using a emulsification/solvent evaporation method. Various concentrations of ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA microparticles and the formulations labeled A, B, C and D, respectively. The microcapsules were characterized for drug loading, particle size, polydispersity index, zeta potential (ZP) and drug release.
Results: The zeta potential of the microparticles were -53, -68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively. Polydispersity index ranged from 0.745 to 0.900. Encapsulation efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3 and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and 72.0 % at 18 h were obtained for batches C and A, respectively.
Conclusion: The study shows that PLGA-loaded with ibuprofen can serve as an alternative carrier for controlled release of ibuprofen.
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