Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Therapeutic effects of Laser and L-carnitine against amiodarone-induced pulmonary toxicity in adult male rats

Walaa AM El-Nahrawy¹, Amr ME Zaher², Sara MR Ali¹

¹Zoology Department, Women's College, Ain Shams University; ²National Heart Institute and National Institute of Laser Enhanced Science, Cairo, Egypt.

For correspondence:- Sara Ali Email: sara.m.refaat@gmail.com Tel:+2021275504599

Received: 7 March 2017 Accepted: 23 June 2017 Published: 31 July 2017

Citation: El-Nahrawy WA, Zaher AM, Ali SM. Therapeutic effects of Laser and L-carnitine against amiodarone-induced pulmonary toxicity in adult male rats. Trop J Pharm Res 2017; 16(7):1565-1571 doi: 10.4314/tjpr.v16i7.14

© 2017 The authors.
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Abstract

Purpose: To compare the effects of laser and/or L-carnitine (LC) on amiodarone (AM)-induced lung toxicity in adult male rats.

Methods: Lung toxicity was induced in 50 healthy male albino rats (150-180 g) by AM for 8 weeks. The rats were divided into 4 groups (7 per group): AM recovery, LC, laser, and laser + LC. After a 4-week exposure to laser and/or LC, key antioxidant enzymes, nitric oxide (NO), angiotensin II, cyclooxygenase-II (COX-II) and lipoxygenase (LOX) as well as oxidative stress and inflammation parameters were determined.

Results: Administration of LC and/or laser exposure led to significant increases in reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and angiotensin II; and significant decreases in nitric oxide (NO) level and glutathione-S-transferase (GST) activity in the AM-treated rats when compared with the AM recovery group (p F6; 0.05). The LC and/or laser exposure also significantly inhibited COX II and LOX activities in the lungs, and brought about significant reduction in levels of TNF-α and lipid peroxidation (LPO), and significant increases in cytochrome levels (p F6; 0.05).

Conclusion: These results indicate that AM induced pulmonary fibrosis in rats. However, AM withdrawal and treatment by LC and/or exposure to laser exerted mitigating effects against the AM-induced fibrosis.R03;R03;R03;R03;R03;R03;

Keywords: Amiodarone, Lung toxicity, Laser; L-carnitine