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Original Research Article | OPEN ACCESS

Effect of chronic alcohol consumption on phosphatidylcholine hydroperoxide content of rat liver and brain

Chang-Won Pyun1, Prabhat Kuar Mandal2, Go-Eun Hong1, Chi-Ho Lee3

1Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 147-701, South Korea; 2Department of Livestock Products Technology, Rajiv Gandhi Institute of Veterinary Education and Research, Pondicherry 605 009, India; 3Animal Resources Research Center, Konkuk University, Seoul, 143-701, South Korea.

For correspondence:-  Chi-Ho Lee   Email: leech@konkuk.ac.kr   Tel:+8224503681

Received: 30 September 2014        Accepted: 26 May 2015        Published: 29 July 2015

Citation: Pyun C, Mandal PK, Hong G, Lee C. Effect of chronic alcohol consumption on phosphatidylcholine hydroperoxide content of rat liver and brain. Trop J Pharm Res 2015; 14(7):1225-1230 doi: 10.4314/tjpr.v14i7.15

© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the correlation between alcohol-induced oxidative stress and tissue phosphatidylcholine hydroperoxide (PC-OOH) content of rat liver and brain. 
Methods: Ten Wistar rats were divided into two groups: one group was given 20 % ethanol (5 g/kg) and the other the same volume of normal saline, orally once a day for 6 weeks. Catalase activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC) and PC-OOH content of liver and brain were determined.
Results: The ethanol-treated group had lower catalase activity and total antioxidant capacity.  MDA level in the liver was 0.33 ± 0.07 μM/mg protein which is significantly (p < 0.05) higher than that of the control group (0.17 ± 0.06 μM/mg protein), but in brain, there was no significant difference. PC-OOH level in the ethanol-treated group was 46.91 ± 12.87 pmol/mg in liver and 71.97 ± 26.12 pmol/mg protein in brain while PC-OOH level of control group was 21.40 ± 10.71 pmol/mg protein in liver and that in brain was 25.29 ± 5.67 pmol/mg protein pmol. Thus, PC-OOH levels in both liver and brain were significantly (p < 0.05) higher than that of control group. PC-OOH content in the liver and brain correlated significantly (p < 0.05) with catalase activity and total antioxidant capacity (TAC). 
Conclusion: The study demonstrates that PC-OOH content in liver and brain tissues may be a marker for alcohol-induced oxidative stress.

Keywords: Alcohal toxicity, Oxidative stress, Phosphatidylcholine hydroperoxide, Liver, Brain, Biomarker

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Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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