Yong Li,
Xin Li,
Jia-Kun Wang,
Yan Kuang,
Ming-Xiu Qi 
For correspondence:- Ming-Xiu Qi Email: qimingxiu@hotmail.com Tel:+866348677950
Received: 23 March 2016 Accepted: 19 July 2017 Published: 31 August 2017
Citation: Li Y, Li X, Wang J, Kuang Y, Qi M. Anti-hepatitis B viral activity of Phyllanthus niruri L (Phyllanthaceae) in HepG2/C3A and SK-HEP-1 cells. Trop J Pharm Res 2017; 16(8):1873-1879 doi: 10.4314/tjpr.v16i8.17
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effectiveness of an ethanol extract of Phyllanthus niruri against hepatitis B viral (HBV) infection in human HepG2/C3A cells.
Methods: An ellagic acid-rich ethanol fraction was obtained from P. niruri (Euphorbiaceae) by extraction and thin-layer chromatography. The anti-HBV activity of the fraction was evaluated in vitro against HepG2/C3A cells. The physicochemical characteristics of the fraction were assessed by nuclear magnetic resonance (1H and 12C-NMR).
Results: The isolated active compound showed a half-maximal inhibitory concentration (IC50) of 120 µg/mL. Ellagic acid had no effect on HBV DNA replication at the concentrations evaluated, and did not inhibit the reproduction of HBV. However, the ethanol fraction inhibited the growth of HBV-infected HepG2/C3A cells.
Conclusion: The findings suggest that the ethanol fraction of P. niruri inhibits HBV, and that the active component is not ellagic acid.
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