Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Arabic translation and cultural adaptation of Liverpool Adverse Events Profile (LAEP) among a sample of epileptic older adults

Yazed Sulaiman AlRuthia¹ , Haya Almalaq¹, Huda Alzahrani¹, Fawaz Al-hussain², Reem AlGasem³, Lama AlMutairi⁴

¹Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; ²Department of Medicine, Neurology Division, College of Medicine, King Saud University, Riyadh, Saudi Arabia; ³Department of Pharmacy, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; ⁴Department of Pharmacy, King Abdulaziz University Hospital, Riyadh, Saudi Arabia.

For correspondence:- Yazed AlRuthia Email: yalruthi@gmail.com Tel:+966114677483

Received: 17 May 2017 Accepted: 26 July 2017 Published: 31 August 2017

Citation: AlRuthia YS, Almalaq H, Alzahrani H, Al-hussain F, AlGasem R, AlMutairi L. Arabic translation and cultural adaptation of Liverpool Adverse Events Profile (LAEP) among a sample of epileptic older adults. Trop J Pharm Res 2017; 16(8):1989-1995 doi: 10.4314/tjpr.v16i8.32

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To validate and culturally adapt Liverpool Adverse Events Profile (LAEP) in Arabic among a sample of elderly patients with epilepsy.

Methods: The face and content validity of the Arabic version of LAEP was ensured by a group of healthcare professionals. Undemented elderly patients (≥ 60 years) with seizure disorders, who are on a single antiepileptic drug (AED), were recruited from two tertiary care centers in Riyadh, Saudi Arabia. Factor analysis was performed to check the construct validity. The reliability was measured using Cronbach’s alpha method.

Results: Seventy-four patients met the inclusion criteria and were interviewed. Most of the participants had generalized seizures (67.57 %), and were either illiterate or with elementary school education (62.16 %). Their mean age was 68.9 years, and 51.35 % were male. About two-thirds of the participants were on either carbamazepine or levetiracetam (66.22 %). Six factors were extracted from the Arabic version of LAEP. Cronbach’s alpha of the Arabic version of LAEP was 0.84. The mean overall LAEP score was 28.9.

Conclusion: The Arabic version of LAEP demonstrates good validity and reliability. Similar studies should examine its validity and reliability among different epileptic patient populations.

Keywords: Adverse drug event, Epilepsy, Older adults, Cronbachâ€™s alpha, Liverpool Adverse Events Profile, Seizure disorders, Carbamazepine, Levetiracetam