Shao-Yun Zhang1,
Hong-Qiang Xia1,
Si-Ling Cui2 
For correspondence:- Si-Ling Cui Email: cuisilingcsl@gmail.com Tel:+866346825700
Accepted: 11 August 2017 Published: 30 September 2017
Citation: Zhang S, Xia H, Cui S. Chloroquine prevents acute kidney injury induced by lipopolysaccharide in rats via inhibition of inflammatory factors. Trop J Pharm Res 2017; 16(9):2149-2154 doi: 10.4314/tjpr.v16i9.15
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the role of chloroquine (CQ) in lipopolysaccharide (LPS)-induced renal injury in rats.
Methods: Rats were assigned to one of four groups (n = 10). Control group was only given saline solution, whereas the model control, LPS + CQ, and LPS + yohimbine (YOH) + CQ groups were administered LPS intraperitoneally. At the end of the study, blood urea nitrogen (BUN) and creatinine (Cr) levels were determined.
Results: CQ treatment significantly decreased the blood concentrations of tissue necrosis factor alpha (TNF-α), interleukin-6 (IL-6), IL-18, BUN, and Cr in the model control rats. There were also significant decreases in the levels of high mobility group protein 1 and kidney injury molecule-1 in the renal injury rats compared to the model control group. However, the inhibitory effects of CQ in the LPS-treated rats were blocked by treatment with YOH, an α-2-adrenergic receptor antagonist.
Conclusions: Treatment with CQ attenuates LPS-induced renal injury by inhibiting inflammatory response.
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