Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of anti-gut inflammatory agent on insulin resistance and lipid profile of mice fed different diets

Wang Zheng^1,2, Bao Zhijun¹

¹Department of Geriatrics and Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai 200040, PR China; ²University of Groningen, University Medical Center Groningen, Department of Pediatrics, Section Molecular Genetics, Groningen 9713AV, The Netherlands.

For correspondence:- Bao Zhijun Email: xinyi8681@sina.cn Tel:+862162483180

Accepted: 31 October 2017 Published: 30 November 2017

Citation: Zheng W, Zhijun B. Effect of anti-gut inflammatory agent on insulin resistance and lipid profile of mice fed different diets. Trop J Pharm Res 2017; 16(11):2651-2658 doi: 10.4314/tjpr.v16i11.12

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To further explore the effect of 5-aminosalicylic acid (5-ASA) treatment on lipid levels in mice fed different diets.

Methods: Groups of 9 - 10 mice each were randomly assigned to 6 different diets, low-fat diet (LFD) with or without 5-ASA, high-fat diet (HFD) with or without 5-ASA, and high-fat high-cholesterol diet (HFC) with or without 5-ASA for 12 weeks.

Results: There were changes in gut microbiota of 5-ASA-treated mice, although gut permeability was similar between treated and non-treated groups. The level of fasting blood glucose, fasting plasma insulin and the curve of glucose tolerance test (GTT) in mice fed LFD, HFD or HFC diet were not affected by 5-ASA treatment. Although plasma lipid levels were similar between 5-ASA consuming and non-5-ASA groups in mice fed LFD and HFD, improved lipid profile was seen in mice that received HFC+5-ASA when compared with mice fed only HFC.

Conclusion: These results indicate that targeting gut inflammation and dysbiosis with 5-ASA neither improves gut barrier nor insulin resistance (IR). Thus, results from therapies for metabolic disorder based on anti-gut inflammation should be interpreted with caution

Keywords: 5-Aminosalicylic acid, Small intestine, High-fat, High-cholesterol diet, Dyslipidemia, Glucose tolerance