Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Potential protective role of hydrogen against cisplatin-induced side effects during chemotherapy: A mini-review of a novel hypothesis for antagonism of hydrogen

Fang Li¹, Tao Li¹ , Chu-Rong Li¹, Xiao-Li Yuan¹, Bo Chen², Jun Zhang¹, Jin-Yi Lang¹

¹Department of Radiation Oncology, Sichuan Cancer Hospital; ²Department of Oncology, Chengdu First People's Hospital, Chengdu 610041, China.

For correspondence:- Tao Li Email: litaocdu@yeah.net Tel:+862885420173

Accepted: 12 October 2017 Published: 30 November 2017

Citation: Li F, Li T, Li C, Yuan X, Chen B, Zhang J, et al. Potential protective role of hydrogen against cisplatin-induced side effects during chemotherapy: A mini-review of a novel hypothesis for antagonism of hydrogen. Trop J Pharm Res 2017; 16(11):2773-2776 doi: 10.4314/tjpr.v16i11.27

© 2017 The authors.
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Abstract

Purpose: To review the potential protective role of hydrogen against cisplatin-induced side effects during chemotherapy.

Methods: We searched PubMed and SCOPUS using the following keywords and combinations in titles, keywords, abstracts and full texts: cisplatin; side effects; chemotherapy; tumor; toxicity; hydrogen; reactive oxidative species; and ischemic reperfusion.

Results: The pathogenesis of cisplatin-induced side effects is suggested based on the increased level of reactive oxidative species (ROS). Cisplatin induces ROS-dependent platelet apoptosis via the extracellular signal-regulated kinase (ERK) signaling pathway, which might have contributed to cisplatin-induced hematotoxicity, and in particular, thrombocytopenia. Molecular hydrogen has been shown to have therapeutic effects against damage to various organs (especially kidney, brain and liver) caused by ischemic reperfusion (IR) through selective elimination of the most cytotoxic ROS hydrogen radicals without affecting other types of ROS involved in signal transduction in vitro and in vivo.

Conclusion: Hydrogen may not only alleviate hematotoxicity in patients with hemorrhagic tendencies during cisplatin-based chemotherapy, but also has a potential protective effect against other side effects induced by cisplatin

Keywords: Reactive oxygen species, Hydrogen radicals, Cisplatin, Hepatotoxicity, Chemotherapy, Side effects, Antagonism