Liang-Mei Li1 
,
Jing Yang2
For correspondence:- Liang-Mei Li Email: drliangmei@hotmail.com Tel:+8653183265046
Accepted: 27 November 2017 Published: 29 December 2017
Citation: Li L, Yang J. Effect of Schisandra chinensis (Turcz) Schisandraceae seed extracts and cisplatin on cytotoxicity, genotoxicity and wound healing in MCF-7 cells. Trop J Pharm Res 2017; 16(12):2843-2847 doi: 10.4314/tjpr.v16i12.7
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: Schisandra chinensis is a plant used in traditional Chinese and Russian medicine. An S. chinensis seed extract was tested for its ability to potentiate the effects of the anticancer agent cisplatin in MCF-7 breast cancer cells.
Methods: S. chinensis seeds were extracted with ethanol and the ethanol was evaporated from the extracts to obtain an aqueous fraction of the S. chinensis seed extract (SCSE). MCF-7 cells were exposed to cisplatin alone or in combination with various concentrations of SCSE. The end points that were measured were cytotoxicity, genotoxicity, and wound healing.
Results: The addition of 10 % SCSE increased the cytotoxicity of cisplatin by increasing MCF-7 cell death by 7 %. The combination of 20 % SCSE and cisplatin completely inhibited wound healing in MCF-7 cells. SCSE alone did not induce DNA fragmentation in MCF-7 cells.
Conclusion: Compounds from S. chinensis seed extracts may mitigate cancer cell proliferation and migration
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