M H Elnaem1 
,
MH Nik Mohamed1,
HZ Huri2,
SM Azarisman3
For correspondence:- M Elnaem Email: drmelnaem@gmail.com Tel:+60193944726
Accepted: 28 November 2017 Published: 29 December 2017
Citation: Elnaem MH, Mohamed MN, Huri H, Azarisman S. Patterns of statin therapy prescribing among hospitalized patients with Type 2 diabetes mellitus in two Malaysian tertiary hospitals. Trop J Pharm Res 2017; 16(12):3005-3011 doi: 10.4314/tjpr.v16i12.27
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To assess the patterns of statin therapy prescribing among hospitalized patients with type 2 diabetes mellitus (T2DM) in two Malaysian tertiary healthcare institutions and to determine compliance with Malaysian treatment guidelines.
Methods: A cross-sectional study was conducted from September to December 2016. The study involved hospitalized T2DM patients aged between 40 to 75 years recruited from the medical wards of two tertiary hospitals in the state of Pahang, Malaysia. Evaluation of statin prescribing was classified as appropriate (statin therapy was prescribed with no concurrent drug interactions) or inappropriate (not receiving any statins, although no contraindications), or potentially inappropriate (drug interactions detected or renal dose adjustment needed).
Results: Among the 393 medical records screened, 65 % had a statin therapy prescription. The evaluation of statins prescribing showed that approximately 35 % of patients were not prescribed statins, contrary to national treatment guidelines. Twenty-six percent of the study cases were given drugs that interacted with statins. Renal dose adjustment of the given statin was needed in 5 % of patients. Finally, only one-third of the patients were prescribed appropriate statin doses.
Conclusion: A significant portion of T2DM hospitalized patients did not receive their recommended statin therapy for cardiovascular disease prophylaxis. Closer monitoring and further dose adjustments are warranted to optimize statin therapy prescribing. Further interventions to improve statin prescribing should be considered
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