Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Health-related quality of life of HIV-infected patients taking different antiretroviral regimens at a tertiary healthcare facility in northern Nigeria

Aminu A Biambo¹ , Maxwell O Adibe², Hamidu M Liman³, Chinwe V Ukwe²

¹Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto; ²Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka; ³Department of Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

For correspondence:- Aminu Biambo Email: biambo.aminu@udusok.edu.ng Tel:+2348065268340

Accepted: 28 February 2018 Published: 31 March 2018

Citation: Biambo AA, Adibe MO, Liman HM, Ukwe CV. Health-related quality of life of HIV-infected patients taking different antiretroviral regimens at a tertiary healthcare facility in northern Nigeria. Trop J Pharm Res 2018; 17(3):549-557 doi: 10.4314/tjpr.v17i3.23

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the health-related quality of life (HRQoL) of patients taking different antiretroviral regimens.

Methods: A cross-sectional descriptive design was used to evaluate HRQoL of patients on Highly Active Antiretroviral Therapy (HAART) at Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto, Nigeria. Data were collected using HIV/AIDS-Targeted Quality of Life instrument between May and November, 2015 from 872 adult outpatients who had been on their regimen for at least 6 months. Data were statistically analysed.

Results: The overall HRQoL score of the patients was 59.40 ± 18.66. Among patients on the first-line regimens, those on TDF + FTC + EFZ (60.52 ± 19.17) and those on TDF + 3TC + EFZ (64.41 ± 18.04) reported the best HRQoL scores. The difference between the scores of patients on the two most utilised regimens; AZT + 3TC + NVP (58.14 ± 18.53) and TDF + 3TC + EFZ (64.41 ± 18.04) was significant (p < 0.05). Among patients on second-line regimens, those on TDF + FTC + LPVr (67.58 ± 14.80) reported the highest HRQoL score.

Conclusion: Patients in this facility had a moderate HRQoL. TDF + 3TC + EFZ, TDF + FTC + EFZ and TDF + FTC + LPVr were the regimens with the best HRQoL outcomes. The use of these regimens should be encouraged for better patient well-being

Keywords: HIV, Health-related quality of life, Antiretroviral therapy, First-line antiretroviral regimen, Second-line antiretroviral regimen