Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Antimicrobial and antioxidant studies of novel mixed-metal complexes of benzoyl-aminoethanoic acid-nicotinamide: Microwave-assisted green synthesis, spectroscopic characterization and molecular modeling

Rayees Ahmad Shiekh¹ , Musa A Said¹, Maqsood Ahmad Malik², Athar Adil Hashmi²

¹Department of Chemistry, Faculty of Science, Taibah University, PO Box 30002, Almadinah Almunawarrah; ²Chemistry Department, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah 21589, Saudi Arabia.

For correspondence:- Rayees Shiekh Email: rayeeschem@gmail.com Tel:+966504439096

Accepted: 1 May 2018 Published: 28 May 2018

Citation: Shiekh RA, Said MA, Malik MA, Hashmi AA. Antimicrobial and antioxidant studies of novel mixed-metal complexes of benzoyl-aminoethanoic acid-nicotinamide: Microwave-assisted green synthesis, spectroscopic characterization and molecular modeling. Trop J Pharm Res 2018; 17(5):865-874 doi: 10.4314/tjpr.v17i5.17

© 2018 The authors.
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Abstract

Purpose: To enhance the antimicrobial and antioxidant activities of benzoylaminoethanoic acid (BAEA) and nicotinamide (NA).

Methods: Complexes of benzoylaminoethanoic acid (BAEA) and nicotinamide (NA) were prepared in a microwave oven. These metal complexes were evaluated by various techniques including 1H and 13C nuclear magnetic resonance spectrometry (NMR), infrared spectrometry (IR), ultraviolet-visible spectrometry (UV), mass spectrometry (MS), thermogravemetric analysis (TGA) and molar conductivity. The synthesized compounds were screened for both antibacterial and antifungal activities using disc diffusion technique. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method was used to assess the antioxidant activity of the complexes.

Results: Based on the results of spectroscopic techniques and physicochemical characterization, these complexes have been named [Cu(NA)2(BAEA)Cl2], [Co(NA)2(BAEA)Cl2], and [Ni(NA)2](BAEA)Cl2], respectively. A model structure with a distorted octahedron was proposed based on the outcome of the magnetic, analytical and spectral analyses. Synthesized metal complexes were more effective and efficient than nicotinamide and benzoylaminoethanoic acid.

Conclusion: Efficiently synthesized mixed metal complexes were prepared using a simple, eco-friendly rapid green chemistry methodology. The newly synthesized complexes have significant antimicrobial activities against the test bacterial and fungal strains.

Keywords: Antimicrobial agents, Antioxidant, Nicotinamide, Benzoylaminoethanoic acid, Mixed ligand complexes, Eco-friendly