Amjad Hussain1 
,
Sadia Latif1,
Nasir Abbas1,
Muhammad Irfan3,
Muhammad Sohail Arshad2,
Nadeem Irfan Bukhari1
For correspondence:- Amjad Hussain Email: amjad_husein@hotmail.com Tel:+924299211616
Accepted: 20 May 2018 Published: 30 June 2018
Citation: Hussain A, Latif S, Abbas N, Irfan M, Arshad MS, Bukhari NI. Hydroxypropyl cellulose-based orally disintegrating films of promethazine HCl for the treatment of motion sickness. Trop J Pharm Res 2018; 17(6):991-996 doi: 10.4314/tjpr.v17i6.2
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To prepare and characterize orally disintegrating films (ODFs) of promethazine hydrochloride (HCl) for prompt treatment of motion sickness.
Methods: Films were prepared by solvent casting method using hydroxypropyl cellulose (HPC) as film former and glycerin as plasticizer along with a saliva stimulating and sweetening agent. Nine different film formulations were prepared and evaluated for their characteristics including thickness, disintegration time, tensile strength and drug release behavior.
Results: The prepared films were transparent and slightly sticky in nature with thickness that ranged from 0.22 mm to 0.29 mm and tensile strength of 0.56 N/cm² to 2.49 N/cm². The disintegration time of film formulations ranged from 26.3 to 52.7 s and a majority of formulations released approx. 80 % of the drug within 10 min with a non-Fickian diffusion pattern.
Conclusion: The study concludes that the orally disintegrating films of promethazine HCl can be prepared using HPC as film former.
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