Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Ameliorative effects of parecoxib in combination with ultrasound-guided paravertebral block (UGPB) on stress and inflammatory responses following thoracoscopic surgery

Xuejie Li^1,2, Xiaoning Cui², Shouhong Zhang², Zhijian Fu¹

¹Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021; ²Department of Anesthesiology, Yantaishan Hospital, Yantai 264000, PR China.

For correspondence:- Zhijian Fu Email: zhijian_fu@163.com Tel:+8653168776580

Accepted: 21 May 2018 Published: 30 June 2018

Citation: Li X, Cui X, Zhang S, Fu Z. Ameliorative effects of parecoxib in combination with ultrasound-guided paravertebral block (UGPB) on stress and inflammatory responses following thoracoscopic surgery. Trop J Pharm Res 2018; 17(6):1171-1175 doi: 10.4314/tjpr.v17i6.25

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the ameliorative effects of parecoxib combined with ultrasound-guided paravertebral block (UGPB) on stress and inflammatory responses after thoracoscopic surgery.

Methods: Forty thoracoscopic surgery patients were randomized into placebo (control) and parecoxib groups. Parecoxib was administered pre-operation, 24 h and 48 h after operation. Arterial blood was collected, and endotoxin (ET), thromboxane A2 (TXA2), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels were measured. Opioid dosage, infusion volume, blood loss, operation time, visual analogue scale (VAS) score at 24 h and 48 h, and hospitalization period were recorded.

Results: No significant differences were observed in age, sex, height, body weight, opioid dosage, surgery time, blood loss, or infusion volume between groups. VAS scores in the parecoxib group were significantly lower than the control group after 24 and 48 h. The hospitalization period of the parecoxib group was significantly shorter than the control group. Plasma levels of ET, TXA2, IL-6 and TNF-α in the parecoxib group were lower than the control group after 24 h; however, there was no significant difference after 48 h.

Conclusion: Parecoxib, combined with UGPB, effectively relieves thoracoscopic pain, stress, and inflammatory responses of patients after thoracoscopic surgery. This treatment would improve the post-operative quality of life of lung cancer patients.

Keywords: Parecoxib, Paravertebral block, Stress response, Inflammatory response