Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of dexmedetomidine hydrochloride combination with conventional anesthesia on serum cortisol, inflammatory factors and cellular immunity during surgery on children with congenital anus atresia

Aihua Liu, Lichuan Tian, Fang Yin

Department of Anaesthesia, Cangzhou People's Hospital, Cangzhou City, China;

For correspondence:- Fang Yin Email: jn1336@163.com

Accepted: 26 June 2018 Published: 28 July 2018

Citation: Liu A, Tian L, Yin F. Effect of dexmedetomidine hydrochloride combination with conventional anesthesia on serum cortisol, inflammatory factors and cellular immunity during surgery on children with congenital anus atresia. Trop J Pharm Res 2018; 17(7):1361-1366 doi: 10.4314/tjpr.v17i7.19

© 2018 The authors.
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Abstract

Purpose: To study the effect of a combination of dexmedetomidine hydrochloride (DXM) and conventional anesthesia on surgical anesthesia in pediatric congenital anoplasty.

Methods: Fifty children with congenital anus atresia were divided into control and study group. Both groups underwent anal angioplasty or colostomy, with the control group under conventional anesthesia, while the study group received both conventional anesthesia and DXM. Heart beat rate, arterial blood pressure, changes in oxygen saturation were recorded. Blood loss were noted. Venous blood was collected at various time points for assay of serum cortisol, IL-6, and T-lymphocyte subsets.

Results: The arterial pressure and heart beat of the study group at T₁ and T₂ were significantly lower than those of the control group (p F6; 0.05). Blood loss was significantly lower in the study group than in the control group (p F6; 0.05). Serum cortisol and IL-6 levels at T₁, T₂ and T₃ in both groups significantly increased, compared with T₀, with levels in the study group significantly lower than those in the control group (p < 0.05). Values of CD3 +, CD4 + and CD4 +/CD8 + in both groups significantly decreased at T₂, when compared with corresponding values at T₀, while the levels in the study group were significantly lower than those in the control group (p < 0.05).

Conclusion: Dexmedetomidine hydrochloride combined with conventional anesthesia is more effective than conventional anesthesia during surgery on congenital anal atresia.

Keywords: Dexmedetomidine hydrochloride, Congenital anal atresia, Cortisol, IL-6, T-lymphocyte subsets