Qinliang Xu1,2,
Xinli Wang2,
Qiang Wu1,
Xiangdong Jian1 
,
Baotian Kan1,
Beijun Gao1,
Ke Wang1
For correspondence:- Xiangdong Jian Email: ih0713@163.com
Accepted: 29 June 2018 Published: 28 July 2018
Citation: Xu Q, Wang X, Wu Q, Jian X, Kan B, Gao B, et al. Urinary paraquat concentration and white blood cell count as prognostic factors in paraquat poisoning. Trop J Pharm Res 2018; 17(7):1391-1396 doi: 10.4314/tjpr.v17i7.24
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of white blood cell (WBC) and urinary paraquat (PQ) levels on prognostic factors in patients exposed to PQ intoxication using multivariate logistic regression analysis.
Methods: A total of 104 subjects intoxicated with PQ between December 2015 and July 2016 were used in this retrospective study. They comprised patients who survived (n = 78), and patients who died (n = 26). Clinical features and prognostic parameters were analyzed in both groups. Multivariate logistic regression analysis was used to establish a prognostic correlation model based on results from single factor variables.
Results: Comparison of demographic and clinical attributes between the two groups, survivors (n = 78) and non-survivors (n = 26), revealed that those who survived were not as old (33.3 ± 9.9 years) as non-survivors (41.5 ± 12.9 years). In addition, on admission, it was found that the survivors ingested lower amounts of PQ (31.6 ± 13.8 ml) than non-survivors (67.88 ± 31.2 ml). There were significant differences between the two groups with respect to WBC, neutrophils, lymphocytes, lactate dehydrogenase (LDH), creatine kinase (CK), amylase, uric acid (UA), pH, partial pressure of oxygen (PaO2), base excess (BE), lactic acid, and D-dimer levels (p < 0.05).
Conclusion: WBC and urine PQ concentration have strong correlation with prognostic factors in PQ poisoning.
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