Jian Huang1,
Li Ren2 
,
Shaobin Zhang1,
Ze Peng1
For correspondence:- Li Ren Email: RJaynandl@yahoo.com
Accepted: 26 July 2018 Published: 31 August 2018
Citation: Huang J, Ren L, Zhang S, Peng Z. Schisandra chinensis polysaccharides attenuate the growth of tuberculosis bacilli in rats via immunity enhancement. Trop J Pharm Res 2018; 17(8):1651-1655 doi: 10.4314/tjpr.v17i8.26
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the effect of Schisandrachinensis polysaccharides (SCPP11) on the growth of tuberculosis (TB) bacilli in a rat model.
Methods: Tuberculosis (TB) was induced by administration of colonies of tubercle bacilli via the inhalation route. SCPP11 was administered at separate doses of 25, 50 and 100 mg/kg to different rat groups, p.o., for 4 weeks. Untreated rats served as TB control. At the end of treatment, assessments were made on the effect of SCPP11 on colony forming unit (CFU), cytokine levels, and population of immune cells present in lung tissue homogenates of the TB-infected rats.
Results: The CFU of TB bacilli was significantly reduced in the lung tissues of SCPP11-treated group, when compared to untreated TB control group. Moreover, SCPP11 attenuated lung tissue levels of inflammatory cytokines, and significantly enhanced immunity, relative to the TB control group.
Conclusion: These results indicate that SCPP11 ameliorates TB by suppressing the growth of tuberculosis bacilli.
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