Ji Yuan,
Zhang Yan,
Tao Gen 
For correspondence:- Tao Gen Email: lf1252@163.com
Accepted: 29 August 2018 Published: 30 September 2018
Citation:
Yuan J, Yan Z, Gen T.
Effect of bupleurum liver-coursing powder on acute gastric ulcer and ex
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the ameliorative effect of bupleurum liver-coursing powder on symptoms of acute gastric ulcer (AGU), and on the ex
Methods: A total of 120 patients were recruited over a 1-year period for this study, and assigned to observation and control groups (60 patients each). The observation group consisted of 31 males and 29 females aged between 23 and 55 years (mean age, 38.77 ± 4.36 years; mean disease history, 7.94 ± 2.49 days). Control group consisted of 33 males and 27 females aged between 26 and 51 years (mean age, 37.68 ± 4.67 years; mean disease history, 8.06 ± 2.31 days). Following 14 days of treatment, clinical symptoms such as gastric swelling and pain, chest distress, belching, and sour regurgitation were recorded and analyzed. Serum levels of C-reactive protein (CRP), IL-6 and TNF-α were assayed using ELISA, while the ex
Results: Total effectiveness (recovery, excellent, effective and ineffective) in observation patients (91.70 %) was significantly higher (p < 0.001) than in control group (65.0 %). Prior to treatment, both groups were comparable with respect to the major symptoms of AGU, and serum levels of CRP, TNF-α and IL-6. However, there were significant reductions in symptoms and serum levels of CRP, TNF-α and IL-6 in bupleurum liver-coursing powder-treated patients, post-treatment (p < 0.05). Similarly, after treatment, there were significant increases in the ex
Conclusion: Bupleurum liver-coursing powder is effective in ameliorating symptoms of AGU, and it enhances the ex
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