Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of combined atorvastatin calcium, Salviae miltiorrhizae and ligustrazine hydrochloride injection in cerebral infarction patients

Linlin Fu¹ , Baojun Zhang², Xiaomin Qiu³

¹Neurology Department; ²Kin Venereal Disease Department; ³Outpatient Department, Affiliated Hospital of Shaoxing University, China.

For correspondence:- Linlin Fu Email: ax0740@163.com

Accepted: 28 August 2018 Published: 30 September 2018

Citation: Fu L, Zhang B, Qiu X. Efficacy of combined atorvastatin calcium, Salviae miltiorrhizae and ligustrazine hydrochloride injection in cerebral infarction patients. Trop J Pharm Res 2018; 17(9):1875-1879 doi: 10.4314/tjpr.v17i9.28

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the effect of a combination of atorvastatin calcium with Salviae miltiorrhizae and ligustrazine hydrochloride injection on serum levels of ferritin (SF), C-reactive protein (CRP) and hypoxia-inducible factor 1α(HIF-1α) in cerebral infarction patients.

Methods: A total of 60 cerebral infarction patients (confirmed by CT or MRI scan) were randomly assigned to control group and observation group (30 patients/group). Both groups received routine treatments. All patients took atorvastatin calcium, but those in the observation group were treated with Salviae miltiorrhizae and ligustrazine hydrochloride injection, in addition to atorvastatin hydrochloride for 14 days, with 7 days as treatment course. The levels of SF, CRP and HIF-1α were determined before and after treatment, to assess clinical efficacy and safety.

Results: In both groups, SF, CRP and HIF-1α levels were lower after treatment than before treatment (p < 0.05). NIHSS score and platelet activation indices were also significantly reduced, relative to control (p < 0.05).

Conclusion: The combination of atorvastatin calcium with Salviae miltiorrhizae and ligustrazine hydrochloride injection can control vascular inflammatory reactions by decreasing the levels of SF, CRP and HIF-1α. Thus, it may be beneficial in the clinical management of cerebral infarction.

Keywords: Cerebral infarction, Atorvastatin calcium, Salviae miltiorrhizae, Ligustrazine hydrochloride injection