Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Serum high-sensitivity C-reactive protein levels in co-morbid patients with type-2 diabetes mellitus and periodontal disease

Tan Jiawei¹, Pan Lulu² , Xu Guochao¹, Xiang Lixin¹

¹Department of Stomatology, Zhejiang Hospital, Hangzhou City 310013; ²Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou City 325000, Zhejiang Province, China.

For correspondence:- Pan Lulu Email: sn1237@163.com Tel:+8615158619497

Accepted: 27 August 2018 Published: 30 September 2018

Citation: Jiawei T, Lulu P, Guochao X, Lixin X. Serum high-sensitivity C-reactive protein levels in co-morbid patients with type-2 diabetes mellitus and periodontal disease. Trop J Pharm Res 2018; 17(9):1881-1884 doi: 10.4314/tjpr.v17i9.29

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the relationship between serum levels of high-sensitivity C-reactive protein (hs-CRP) and the severity of periodontal disease in diabetics with periodontitis.

Methods: Ninety patients were recruited for this study. They were divided into three groups, namely, group 1 (30 patients with type 2 diabetes mellitus (T2DM) and periodontal disease), group II (30 patients with T2DM only) and control (30 healthy individuals). Serum levels of hs-CRP and glycosylated hemoglobin (HbAc) were determined. Moreover, blood glucose (BG) and insulin (FNS) levels were determined in the fasted state, and their values used to compute insulin resistance index (Homa-IR).

Results: Serum levels of FNS, FPG, HbAc and Homa-IR in group I patients were significantly higher (p < 0.05) than those of control group. While the levels of BG and Homa-IR in the serum of patients in groups I and II were significantly higher (p < 0.05) than those of control, marked reductions were seen in their values in group II, relative to group I. The serum levels of hs-CRP in group I and II were significantly increased (p < 0.05) relative to control, but were lower in group II than in group I (p < 0.05). Homa-IR was positively correlated with serum hs-CRP, FNS, BG, HbAc, and Homa-IR in groups I and II. Results from multiple regression analysis revealed significant effects of hs-CRP and HbAc on Homa-IR.

Conclusion: Serum levels of hs-CRP in patients with T2DM and periodontitis are closely related to disease severity, insulin resistance and blood glucose level

Keywords: Type-2 diabetes mellitus, Periodontal disease, High-sensitivity C-reactive protein, Blood glucose, Insulin resistance, Correlation