Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of a combination of Xiaochaihu decoction and teprenone on peripheral blood T lymphocytes in chronic atrophic gastritis, and on expression of COX-2 in gastric mucosa

Weng Weian, Yu Xiaoxiao

Department of Traditional Chinese Medicine, Ruian people's Hospital, No. 108, Wan Song Road, Ruian 325200, China;

For correspondence:- Yu Xiaoxiao Email: hv1290@163.com

Accepted: 28 September 2018 Published: 31 October 2018

Citation: Weian W, Xiaoxiao Y. Effect of a combination of Xiaochaihu decoction and teprenone on peripheral blood T lymphocytes in chronic atrophic gastritis, and on expression of COX-2 in gastric mucosa. Trop J Pharm Res 2018; 17(10):2007-2012 doi: 10.4314/tjpr.v17i10.16

© 2018 The authors.
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Abstract

Purpose: To study the effects of the combined use of Xiaochaihu decoction and teprenone on peripheral blood T lymphocytes in chronic atrophic gastritis (CAG) and gastric mucosal expression of cyclooxygenase-2 (COX-2).

Methods: Patients with CAG who were treated at Traditional Chinese Medicine Hospital of Jiaxing from January 2017 to January 2018 were used as subjects. They consisted of observation and control groups (99 patients per group). Both groups were treated with teprenone (50 mg, thrice daily), but patients in the observation group received 200 mL of Xiaochaihu decoction, in addition to teprenone. The treatments were given orally, and lasted for 3 weeks. Comparisons were made between the two groups with respect to the effects of the treatments on peripheral blood T lymphocytes, CAG, and quality of life.

Results: Peripheral T lymphocytes, chronic atrophic gastritis and quality of life in patients in the observation group were significantly improved, relative to control group patients. The combined treatment led to a significant decrease in the expression of COX-2. After treatment, there was upregulation in CD3⁺, CD4⁺ and CD4⁺/CD8⁺ levels in both groups, relative to the corresponding levels prior to drug exposure (p < 0.05). However, the observation group levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺were higher than corresponding control values (t = -14.45, p < 0.001; t = -12.47, p < 0.001; t = -3.49, p < 0.001, respectively). Moreover, results from histopathological studies showed marked improvement in the observation group.

Conclusion: A combination treatment of Xiaochaihu decoction and teprenone improves the condition of CAG patients via changes in peripheral blood lymphocytes and COX-2 expression in gastric mucosa.

Keywords: Xiaochaihu decoction, Teprenone, Chronic atrophic gastritis, T lymphocytes, Cyclooxygenase-2