Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-thrombotic effect of combination of low molecular heparin and Xueshuantong after replantation of amputated finger

Sun Huanwei, Yang Weidong, Zhang Hongquan, Wang Chunsheng, Zhong Yiming, Su Yi, Gao Bing, Sun Yang , Zou Xiaowei

Dalian Municipal Central Hospital Affliated of Dalian Medical University, Hand and Foot Surgery, Dalian, Liaoning 116033, China;

For correspondence:- Sun Yang Email: uo1268@163.com

Accepted: 29 October 2018 Published: 30 November 2018

Citation: Huanwei S, Weidong Y, Hongquan Z, Chunsheng W, Yiming Z, Yi S, et al. Anti-thrombotic effect of combination of low molecular heparin and Xueshuantong after replantation of amputated finger. Trop J Pharm Res 2018; 17(11):2249-2254 doi: 10.4314/tjpr.v17i11.20

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the effects of low molecular heparin combined with Xueshuantong in preventing thrombosis after replantation of amputated finger.

Methods: The treatment group (38 patients) was given 4500 IU of low molecular heparin sodium i.h. (hypodermic injection), q.d.(once daily), with 200 mL of 150 mg Xueshuantong injection and 5 % glucose injection, i.v.d. (intravenous drip), b.i.d. (twice daily). The control group received low molecular heparin sodium at 4500 IU i.h., q.d. alone. Treatment was for 3 days. Thereafter, D-dimer, fibrinogen, hemoglobin, platelets, prothrombin time (PT) and blood coagulation of patients in the 2 groups before and after treatment were compared. Differences in vasospasm, vascular thrombosis, finger necrosis, therapeutic effects and adverse reactions in patients in the 2 groups after treatment were recorded.

Results: There were significant improvements in fibrinogen, platelet, PT levels, and blood coagulation time after treatment, with improvements better in the treatment group than in the control group (p < 0.05). Vasospasm cases (3) were lower in the treatment group than in the control group (8, p < 0.05), while vascular thrombosis and finger necrosis in both groups were comparable. Therapeutic effects and recovery were better in the treatment group than in the control group (p < 0.05).

Conclusion: Combined injection of Xueshuantong and low molecular heparin exerts antithrombotic effects after replantation of amputated finger, improves coagulation function, and reduces incidence of vasospasm. It has better therapeutic effects than low molecular heparin, and it seems safe.

Keywords: Xueshuantong, Low molecular heparin, Replantation, Amputated finger, Thrombosis