Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of serum cystatin C and chromogranin A on left ventricular mass index in patients with chronic heart failure

Xue Xiaoxuan, Liu Yan

Dongfang Hospital, Beijing University of Traditional Chinese Medicine, No. 6, Fangxingyuan District 1, Fangzhuang District, Fengtai District, Beijing 100078, China;

For correspondence:- Liu Yan Email: hs1253@163.com

Accepted: 22 October 2018 Published: 30 November 2018

Citation: Xiaoxuan X, Yan L. Effect of serum cystatin C and chromogranin A on left ventricular mass index in patients with chronic heart failure. Trop J Pharm Res 2018; 17(11):2263-2267 doi: 10.4314/tjpr.v17i11.22

© 2018 The authors.
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Abstract

Purpose: To investigate the expression of serum cystatin C (CystC) and chromogranin A (CgA) in chronic heart failure (CHF) patients, and their correlation with left ventricular mass index (LVMI).

Methods: CHF patients (135) in the study hospital were randomly selected, and assigned to different groups on the basis of heart function grade (grades II to IV). Grades II, III and IV had 45 patients each. In addition, 45 people with normal physical examination results were assigned to the control group. In all patients, N-terminal natriuretic peptide (NT-proBNP), CysC and CgA were measured. In addition, left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), and left ventricular ejection fraction (LVEF) were measured using transthoracic echocardiography, and the results were used to calculate LVMI values.

Results: There were significantly higher levels of CystC and CgA in CHF patients than in control patients (p < 0. 05). In grade IV patients, CystC and CgA levels were higher than the corresponding levels in patients with cardiac function grades II and III, while their levels in grade III patients were higher than in grade II patients (p < 0.05). The results of correlation analysis indicated that serum CgA was positively correlated with serum CystC. Serum CgA and CystC levels in CHF patients were negatively correlated with LVEF, but positively correlated with NT-proBNP and LVMI levels.

Conclusion: Serum CgA and CysC are correlated with cardiac function grade and ventricular remodeling in CHF patients. Thus, to some extent, these two indices can be used to measure the degree of ventricular remodeling in CHF individuals.

Keywords: Chromogranin A (CgA), Heart failure, Cystatin C (CysC), Left ventricular mass index