Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Myricetin promotes peripheral nerve regeneration in rat model of sciatic nerve injury via regulation of BDNF-Akt/GSK-3β/mTOR signalling pathway

Dechou Zhang¹, Jianhua Ge² , Lisha Ye¹, Hongmei Tang¹, Xue Bai¹

¹Department of Cardiology and Encephalopathy, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University; ²Department of Bone and Joint, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China.

For correspondence:- Jianhua Ge Email: JessenParkertj@yahoo.com Tel:+868302292219

Accepted: 21 November 2018 Published: 26 December 2018

Citation: Zhang D, Ge J, Ye L, Tang H, Bai X. Myricetin promotes peripheral nerve regeneration in rat model of sciatic nerve injury via regulation of BDNF-Akt/GSK-3β/mTOR signalling pathway. Trop J Pharm Res 2018; 17(12):2355-2363 doi: 10.4314/tjpr.v17i12.6

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effects of myricetin on peripheral nerve regeneration in sciatic nerve crush injury model.

Methods: Separate groups of rats were administered myricetin at 25, 50 or 100 mg/kg body weight/day for 2 weeks. Functional recovery following sciatic nerve injury was assessed by foot position and walking track analyses, measurement of mechanical hyperalgesia, and withdrawal reflex latency (WRL).

Results: Myricetin treatment resulted in significantly enhanced recovery of sensorimotor functions as evidenced by increased scores in functional analysis tests. Myricetin treatment remarkably elevated brain derived neurotrophic factor (BDNF) expression, and also enhanced activation of Akt and mTORc1, reflecting up-regulation of PI3K/Akt/mTORC1 signalling involved in nerve regeneration.

Conclusion: Myricetin enhances functional recovery and nerve regeneration in rats. These findings suggest that myricetin is a potent neuroprotective agent with potential for the management of peripheral nerve injury.

Keywords: Glycogen synthase kinase 3β, Mammalian target of rapamycin (mTOR), Myricetin, Nerve regeneration