Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Notoginseng root enhances healing in imiquimod-induced psoriasis mice model via anti-inflammatory and anti-proliferative properties

Yangqi Li¹, Xianglong Dai¹, Jinliang Li², Jinghang Deng¹, Changlan Wan³, Xia Xu¹, Fengxing Liang², Fei Wang¹, Jinbao Zhong²

¹Department of Dermatology; ²Department of Traditional Chinese Medical Dermatology; ³Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, China.

For correspondence:- Jinbao Zhong Email: jinbaozhong68@hotmail.com Tel:862083583564

Accepted: 19 November 2018 Published: 26 December 2018

Citation: Li Y, Dai X, Li J, Deng J, Wan C, Xu X, et al. Notoginseng root enhances healing in imiquimod-induced psoriasis mice model via anti-inflammatory and anti-proliferative properties. Trop J Pharm Res 2018; 17(12):2365-2370 doi: 10.4314/tjpr.v17i12.7

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the beneficial effect of Panax notoginseng (PN) gel against imiquimod-induced psoriasis in a mice model.

Methods: Psoriasis was induced by topical application of imiquimod cream (5 %) on the shaved skin of mice for 7 days. PN group received PN gel (1 %) twice a day with imiquimod cream (5 %) once a day for one week. The effect of PN gel was estimated by scoring skin thickness, scaling and erythema. Reverse transcription polymerase chain reaction (RT-PCR) was used for the determination of the expressions of inflammatory mediators in skin tissues of mice. Moreover, the severity of inflammation was determined by histopathological and immunohistochemical assessment of skin tissues.

Results: The severity of inflammation and the expressions of inflammatory mediators were significantly reduced in PN gel-treated group, relative to the negative control group. Treatment with PN gel attenuated the histopathology of skin tissue in the imiquimod-induced psoriatic mice, and significantly decreased the level of intercellular adhesion molecule (ICAM-1), when compared to the negative control group.

Conclusion: These results show that PN gel attenuates psoriasis in imiquimod-induced psoriasis mice model by decreasing skin inflammation. Thus, PN gel may be suitable for the management of psoriasis.

Keywords: Psoriasis, Panax notoginseng, Inflammatory mediators, Imiquimod, Intercellular Adhesion Molecule-1