Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

A double-blinded, randomized, placebo-controlled study evaluating the impact of dates vinegar consumption on blood biochemical and hematological parameters in patients with type 2 diabetes

Zeshan Ali¹ , Haile Ma², Ishmael Ayim⁴, Muhammad Tayyab Rashid⁵, Asif Wali³, Shoaib Younas⁶,

¹School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; ²Department of Agriculture and Food Technology, Karakoram International University, Gilgit 15100, Pakistan; ³Department of Food Science and Nutrition, University of Sargodha, Pakistan.

For correspondence:- Zeshan Ali Email: mhl@ujs.edu.cn

Accepted: 11 September 2018 Published: 27 December 2018

Citation: Ali Z, Ma H, Ayim I, Rashid MT, Wali A, Younas S, A double-blinded, randomized, placebo-controlled study evaluating the impact of dates vinegar consumption on blood biochemical and hematological parameters in patients with type 2 diabetes. Trop J Pharm Res 2018; 17(12):2463-2469 doi: 10.4314/tjpr.v17i12.23

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the effects of dates vinegar on blood biochemical and hematological parameters in type 2 diabetic subjects.

Methods: Current research focused on fifty-five subjects having blood sugar more than126 mg/dL. Participants ingested dates vinegar (20 mL) daily into their normal diets for a period of 10 weeks. Glycated hemoglobin (HbA1c), fasting blood sugar (FBS), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine (Cr), urea, complete blood count (CBC), alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), potassium and folate levels were analyzed before, after 5 weeks and after the experiment

Results: Dates vinegar improved the blood concentrations of HbA1c (6.80 ±2.34 to 6.17 ± 2.14 (%)), FBS (171.43 ±36.74 to 147.56 ± 38.86 mg/dL,p=0.001), TC (218.10 ± 16.9 to 191.14 ± 14.23 mg/dL, p<0.001), ALT (24.94 ± 5.03 to 21.88±5.08 IU/L, p=0.002) and ALP (264.32± 45.26 to 257.30 ±44.21 IU/L) and folate (34.6 ± 6.6 to 41.7 ± 6.5 nmol/ L,p<0.001).

Conclusion: Dates vinegar significantly improved the total cholesterol.The other blood biochemical and hematological factors were also improved however; the improvements were not significant.

Keywords: Dates vinegar, diabetes, glycated hemoglobin, hyperlipidemia