Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Identification of heat-resistant chemical components of Ferula elaeochytris root extracts by gas chromatography- mass spectrometry

Nadire Eser¹ , Atila Yoldas²

¹Department of Pharmacology; ²Department of Anatomy, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

For correspondence:- Nadire Eser Email: esernadire01@hotmail.com

Accepted: 19 December 2018 Published: 31 January 2019

Citation: Eser N, Yoldas A. Identification of heat-resistant chemical components of Ferula elaeochytris root extracts by gas chromatography- mass spectrometry. Trop J Pharm Res 2019; 18(1):55-60 doi: 10.4314/tjpr.v18i1.9

© 2019 The authors.
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Abstract

Purpose: To determine the chemical composition of Ferula elaeochytris, a plant with traditional medicinal uses, and to investigate its potential benefits.

Methods: Ferula elaeochytris specimens were collected from Engizek plateau of Kahramanmaras, Turkey in early June 2017, and dried in a cool and dry place at room temperature. Once dried, they were ground into a powder using a plant grinder. A Soxhlet extractor was employed for extraction of the powdered roots using diethyl ether solvent for 4 h, and then subsequently evaporated using a rotary evaporator. The extract was analysed by gas chromatography–mass spectrometry (GC-MS) to reveal the components of F. elaeochytris.

Results: Khusinol, ferutinin and beta-ionone, components with anti-inflammatory phytoestrogen, antiproliferative and antioxidant activities, were found in high levels (25.9, 13.9 and 22.9 %, respectively) in F. elaeochytris root extract. In addition, α-pinene, which has anti-inflammatory, bronchodilator, hypoglycaemic and anticarcinogenic effects, was found at lower levels (12.9 % or less).

Conclusion: The results reveal the presence of some therapeutically beneficial components of F. elaeochytris root extract, including compounds with antioxidant and anti-inflammatory effects.

Keywords: Ferula elaeochytris, Khusinol, Ferutinin, Beta-ionone, Anti-inflammatory Phytoestrogen, Antiproliferative, Antioxidant