Bo Zhao1,
Baozhu Su1,
Hui Zhang2,
Wei Liu2,
Qiao Du2,
Yingyi Li1 
For correspondence:- Yingyi Li Email: iuw0303bj@sina.com
Accepted: 24 December 2018 Published: 31 January 2019
Citation: Zhao B, Su B, Zhang H, Liu W, Du Q, Li Y. Antiurolithiatic effect of ferulic acid on ethylene glycol-induced renal calculus in experimental rats. Trop J Pharm Res 2019; 18(1):109-115 doi: 10.4314/tjpr.v18i1.16
© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the anti-urolithiatic effect of ferulic acid on ethylene glycol-induced kidney stone in a rat model.
Methods: Five groups of adult male Sprague-Dawley rats (6 rats/group) were used in this study. Group I rats served as normal control. Renal calculus was induced through ethylene glycol (0.75 % v/v in drinking water) administration to all rats for 28 days except those in group 1. Prior to ethylene glycol treatment, ferulic acid was given orally (gavage) to rats in groups III and IV at doses of 40 and 80 mg/kg, respectively. Rats in group V (positive control) were treated with standard drug, cystone at a dose of 750 mg/kg prior to ethylene glycol administration, while group II rats received no treatment. Kidney tissue and blood serum were sampled after 28 days and used for biochemical and histopathological analyses.
Results: Rats in group II showed significant increases in oxidative stress pattern as seen in significant reductions in GSH, SOD, GPx, and CAT levels, and significant elevation of lipid peroxidation (LPO), relative to normal control group (p < 0.05). However, renal calculus formation and oxidative stress were significantly inhibited by ferulic acid treatment in groups III and IV. These results were supported by histopathological findings.
Conclusion: Ferulic acid exerts anti-urolithiatic effect via inhibition of oxidative stress. Thus, it has potentials for use in preventing kidney stone formation.
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