Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effectiveness of triple inhalation therapy and non-invasive ventilation in the treatment of acute exacerbated chronic obstructive pulmonary disease

Zhang Lin, Nie Xiuhong , Luo Zhiming, Wei Bing, Teng Guojie

Department of Respiratory Medicine, Xuanwu Hospital Capital Medical University, Beijing, China;

For correspondence:- Nie Xiuhong Email: tz1174@163.com

Accepted: 27 December 2018 Published: 31 January 2019

Citation: Lin Z, Xiuhong N, Zhiming L, Bing W, Guojie T. Effectiveness of triple inhalation therapy and non-invasive ventilation in the treatment of acute exacerbated chronic obstructive pulmonary disease. Trop J Pharm Res 2019; 18(1):141-144 doi: 10.4314/tjpr.v18i1.21

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the clinical effectiveness of combining triple inhalation therapy with non-invasive ventilation in treating acute exacerbated chronic obstructive pulmonary disease (AECOPD).

Methods: A total of 128 AECOPD patients admitted in the Department of Respiratory Medicine of our Hospital were involved in the study. Two groups of patients were used (64 patients per group). The study group was given triple inhalation therapy and non-invasive ventilation, while only non-invasive ventilation was given to the control group. The curative effects of the two treatments and their effects on arterial Pa_CO2 (partial pressure of carbon dioxide), pH and Pa_O2 (partial pressure of oxygen) were determined.

Results: The study group showed significantly higher treatment effectiveness than the control group (p < 0.05). Post-treatment Pa_CO2, pH, Pa_O2, respiratory rate and heart rate differed significantly between the two groups (p < 0.05). Improvements in the five indices were more in the study group than in the control group (p < 0.05).

Conclusion: Combining triple inhalation therapy with non-invasive ventilation in the treatment of AECOPD enhances therapeutic effect, improves pulmonary ventilation, and reduces side effects.

Keywords: Chronic obstructive pulmonary disease, Acute exacerbation, Triple inhalation, Non-invasive ventilation