Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effects of sevoflurane and propofol on hemodynamics, cerebral oxygen metabolism and analgesia during maintenance of paediatric anaesthesia

Si Zhenqiang , Sun Fei, Liu Lu

Department of Anaesthesiology, Children's Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing 210008, Jiangsu Province, China;

For correspondence:- Si Zhenqiang Email: ra1278@163.com

Accepted: 31 December 2018 Published: 31 January 2019

Citation: Zhenqiang S, Fei S, Lu L. Effects of sevoflurane and propofol on hemodynamics, cerebral oxygen metabolism and analgesia during maintenance of paediatric anaesthesia. Trop J Pharm Res 2019; 18(1):187-192 doi: 10.4314/tjpr.v18i1.28

© 2019 The authors.
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Abstract

Purpose: To investigate the effects of sevoflurane and propofol on hemodynamics, cerebral oxygen metabolism and analgesia during maintenance of paediatric anaesthesia.

Methods: A total of 134 paediatric patients undergoing surgical anaesthesia in the General Surgery Department of Children’s Hospital of Nanjing Medical University from July 2016 to July 2017 were anesthetised with propofol (control group, n = 67) or sevoflurane (study group, n = 67). The hemodynamics, cerebral oxygen metabolism index, analgesic effect and adverse reaction were determined in both groups and compared.

Results: Heart rate (HR) differed significantly between the two groups in the A3 stage (p < 0.05). Systolic and diastolic blood pressures (SBP and DBP) were statistically different between the two groups in the A2 stage (p < 0.05). In the A2 and A3 stages, jugular venous blood oxygen saturation (SjvO₂) was higher in the study group, and the differential between arterial oxygen and jugular venous blood oxygen saturation (Da-jvO₂) and cerebral oxygen extraction rate (CERO₂) were lower than corresponding values in the control group (p < 0.05). In both groups of patients, SjvO₂ in A3 stage was lower than that in A2 stage (p < 0.05), and Da-jvO₂ and CERO₂ were higher in A3 stage than those in A2 stage (p < 0.05).

Conclusion: Sevoflurane and propofol maintain balance in cerebral oxygen metabolism and hemodynamic stability when used as paediatric anaesthesia. However, sevoflurane is superior to propofol in protecting the brain tissue of children from damage.

Keywords: Propofol, Sevoflurane, Hemodynamics, Cerebral oxygen metabolism, Analgesic