Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Therapeutic effect of co-administered salvianolate and atorvastatin calcium on coronary heart disease patients with angina pectoris, and their blood lipid levels``

Guangyu Cheng¹, Qingjie Li¹, Lin Li¹, Qi Wang², Aidong Liu³

¹Research Center of Traditional Chinese Medicine, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021; ²College of Chinese Material Medicine, Jilin Agricultural University, Jilin 130117; ³The Department of Cardiology, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, China.

For correspondence:- Aidong Liu Email: ps1167@163.com

Accepted: 21 January 2019 Published: 28 February 2019

Citation: Cheng G, Li Q, Li L, Wang Q, Liu A. Therapeutic effect of co-administered salvianolate and atorvastatin calcium on coronary heart disease patients with angina pectoris, and their blood lipid levels``. Trop J Pharm Res 2019; 18(2):371-375 doi: 10.4314/tjpr.v18i2.21

© 2019 The authors.
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Abstract

Purpose: To investigate the clinical effect of combination of salvianolate and atorvastatin on blood lipids of coronary heart disease patients with angina pectoris (CHD-AP).

Method: Patients with CHD-AP (n = 104) from January 2016 to January 2017 were randomly assigned to two groups: control group treated with atorvastatin (10 mg/day), and study group was administered atorvastatin (10 mg/day, oral) plus salvianolate (200 mg/day in 5 % glucose, iv). Palpitation, chest distress, improvement in myocardial ischemia, myocardial function, and hemodynamics were determined and used to assess treatment effectiveness in the two groups. Differences in blood lipid profiles were also investigated.

Results: Improvement in palpitation, chest distress, myocardial ischemia and myocardial function in the study group were significantly higher than in the control group (p < 0.05). In the study group, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triacylglycerols (TGs) significantly decreased, relative to the control group (p < 0.05).

Conclusion: Treatment of CHD-AP patients with combination of salvianolate and atorvastatin significantly ameliorates coronary heart disease and angina pectoris, and also reduces their blood lipid levels.

Keywords: Salvianolate, Atorvastatin, Coronary heart disease, Angina pectoris, Blood lipids