Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Meta-analysis of effectiveness of traditional Chinese medicine or its combination with Western medicine in the treatment of triple negative breast cancer

Wang Yukun¹, Yao Chang², He Fan³, Zeng Jiayao¹

¹Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530023; ²Department of Breast Surgery, Jiangsu Province Traditional Chinese Medicine Hospital, Nanjing, Jiangsu 210029; ³Department of General Surgery, Jiashan First People's Hospital, Jiashan, Zhejiang 314100, China.

For correspondence:- Zeng Jiayao Email: nl1196@163.com

Accepted: 28 February 2019 Published: 31 March 2019

Citation: Yukun W, Chang Y, Fan H, Jiayao Z. Meta-analysis of effectiveness of traditional Chinese medicine or its combination with Western medicine in the treatment of triple negative breast cancer. Trop J Pharm Res 2019; 18(3):639-645 doi: 10.4314/tjpr.v18i3.28

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To assess the efficacy and side effects of Traditional Chinese Medicine (TCM) in the management of triple negative breast cancer (TNBC).

Methods: Full text data on randomized controlled trial (RCT) of TNBC treated with TCM or its combination with Western Medicine (WM) were retrieved from the Chinese biomedical literature database, Chinese periodicals, Chinese Science-Technology periodicals and VP and PubMed. The qualities of the RCTs were evaluated. Revman 5.3 was used to conduct the meta-analysis.

Results: A total of 16 RCTs involving 1186 patients were included. Analysis of these RCTs showed significant differences in total effectiveness between WM and TCM or combination of TCM with WM {(OR = 2.63, 95 % CI = 1.37, 5.03), test of the combined effect (Z = 2.91, p F6; 0.005)}.

Conclusion: The results show that TCM is effective in the treatment TNBC.

Keywords: Triple negative breast cancer, Chinese medicine therapy, Meta-analysis, Randomized controlled trial