Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Determination of sun protection factor and physical remanence of dermocosmetic emulgels formulated with Manilkara zapota (L.) fruit extract

Muhammad Kashif , Naveed Akhtar

Department of Pharmacy, Faculty of Pharmacy and Alternative Medicines, The Islamia University of Bahawalpur 63100, Punjab, Pakistan;

For correspondence:- Muhammad Kashif Email: kashif_pharmd@yahoo.com Tel:+923336362023

Accepted: 19 April 2019 Published: 30 April 2019

Citation: Kashif M, Akhtar N. Determination of sun protection factor and physical remanence of dermocosmetic emulgels formulated with Manilkara zapota (L.) fruit extract. Trop J Pharm Res 2019; 18(4):809-816 doi: 10.4314/tjpr.v18i4.18

© 2019 The authors.
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Abstract

Purpose: To develop a stable emulgel formulation from Manilkara zapota fruit extract (MZFE) and evaluate its sun-protective factor (SPF) and its physical retention on facial skin.

Methods: Active test formulations containing MZFE and placebo (containing no active ingredients) were prepared by dispersing the primary emulsion into a gel phase. Both test and placebo emulgel formulations were subjected to physicochemical evaluation, stability studies, and assessment of possible photo-protective properties. The sun-protective factor (SPF) was determined in vitro by spectrophotometric analysis. Non-invasive in vivo skin bioengineering technique was used to assess the UV-quenching effects of the test and placebo emulgel formulations.

Results: A stable and cosmetically acceptable emulgel formulation loaded with MZFE was obtained. The formulation and control exhibited optimum physicochemical stability in stress stability tests. The formulation exhibited promising photo-protective effects both in vitro (SPF = 14.215 ± 0.140) and in vivo (lasted for approximately 120 min).

Conclusion: The developed MZFE-loaded test emulgel formulation possesses suitable photo-protection capability in vitro, and displays quenching effects against specific wavelengths of UV light, indicating a UV-filtering property.

Keywords: Manilkara zapota, Emulgel, Stability testing, Photo-protection, Sun Protection Factor