Mumuni A Momoh1 
,
Salome A Chime2,
Daniel U Ogbodo1,
Pricillia K Akudike1,
Stanley U Udochukwu1,
Emmanuel C Ossai3,
Franklin C Kenechukwu1,
Kenneth C Ofokansi1,
Anthony A Attama1
For correspondence:- Mumuni Momoh Email: audu.momoh@unn.edu.ng Tel:+2348037784357
Accepted: 15 April 2019 Published: 31 May 2019
Citation: Momoh MA, Chime SA, Ogbodo DU, Akudike PK, Udochukwu SU, Ossai EC, et al. Biochemical, rheological and hydrophile-lipophile balance (HLB) evaluation of Archachatina marginata (snail) mucin extract for possible nutraceutical and nano biopharmaceutical applications. Trop J Pharm Res 2019; 18(5):927-934 doi: 10.4314/tjpr.v18i5.3
© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the rheological, biochemical, hydrophile-lipophile balance (HLB) of Archachatina marginata (snail) mucin extract for possible use as a nutraceutical and nano biopharmaceutical material.
Methods: Snail mucin was extracted with acetone and water, lyophilized and the biochemical, proximate and mineral analyses of the extracts were studied using standard methods. The rheological properties of the extracts (1, 2, 4 and 8 % w/v) and their emulsion-based preparations were evaluated. Other physicochemical properties and HLB values of the preparations were also determined.
Results: Snail mucin extracts contained protein (84 %), fats (2.91 %) and carbohydrate (1.2 %) and showed significant nutraceutical composition (p < 0.05). Ash content of 4.21 and 4.12 % was obtained for water and acetone extracts, respectively. Moisture content was < 9 % for both the aqueous and non-aqueous mucin extracts. Potassium, calcium and phosphorus were present in high quantities in the extracts while iron, copper and zinc were in trace amounts (< 4 %). Mucin dispersions exhibited viscosity in the range of 0.89 to 0.93 cp. Water sorption and dry weight were higher in the acetone extract than in the aqueous extract. The HLB values, which ranged from 7 to 15, were within the acceptable values for material for nanobiopharmaceutical application, except that the acetone extract.
Conclusion: Snail mucin exhibits good nutraceutical properties and also possesses good properties that render it a potential excipient for use in the formulation of drug delivery systems.
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