Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Histopathological changes associated with exposure of some viscerals and testicular tissues to bisephenol A and di(2-ethylhexyl)phthalate

Nosa Terry Omorodion^1,3 , Blessing Emosho Atoigwe-Ogeyemhe^2,3, Peter Uwadiegwu Achukwu², Efosa Bolaji Odigie³,

¹Health Services Department, University of Benin, Ugbowo, Benin City 300001; ²Department of Medical Laboratory, Faculty of Health Sciences and Technology, University of Nigeria, Enugu Campus, Enugu; ³Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Medicine, University of Benin, Benin City 300001, Nigeria.

For correspondence:- Nosa Omorodion Email: terry.omorodion@uniben.edu Tel:+2348136742270

Accepted: 22 May 2019 Published: 30 June 2019

Citation: Omorodion NT, Atoigwe-Ogeyemhe BE, Achukwu PU, Odigie EB, Histopathological changes associated with exposure of some viscerals and testicular tissues to bisephenol A and di(2-ethylhexyl)phthalate. Trop J Pharm Res 2019; 18(6):1213-1218 doi: 10.4314/tjpr.v18i6.10

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the pathological effect associated with the exposure of viscerals and testicular tissues of albino rats to BPA and DEHP.

Methods: A total of sixty adult male Wistar rats weighing 200 – 250 g were divided into four (4) groups of 15 rats per cage in a sanitized environment. Group I animals received normal rodent pellet and water and served as untreated group. Thereafter, the rats in the second group (II) were administered 5 mg/kg per day of BPA mixed with rodent pellet orally; group III received 0.5 mg/kg daily dose of DEHP mixed with rodent pellet; while group IV received orally mixture of 0.5 mg/kg of BPA and 0.5 mg/kg DEHP + pelleted rodent feed. The rats were fed and water provided regularly for 30 days; finally, the animals were weighed and sacrificed by cranial dislocation.

Result: BPA and DEHP resulted in significant (p < 0.05) weight losses, inflammation and fatty deposits in the liver, degenerated bowman capsule and glomeruli of the kidneys, lung oedema, and deteriorated leydig cells in testes.

Conclusion: The results suggest that BPA and DEHP cause significant weight loss and are injurious to the cellular make-up of rat tissues, which may be the same in higher animals.

Keywords: Bisphenol A, Di (2-Ethylhexyl) phthalate, Testicular tissues and Viscerals