Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of albumin administration on post-operation mortality, duration on ventilator, and hospital stay on patients in cardiac intensive care: An observational study

Zhen Zhang¹, Xinlun Dai², Ji Qi¹, Yu Ao¹, Chunfeng Yang¹, Yumei Li¹

¹Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University; ²Clinical Medical College, Jilin University, Changchun, Jilin 130021, China.

For correspondence:- Yumei Li Email: yumei5li@yahoo.com Tel:+8643188783975

Accepted: 16 May 2019 Published: 30 June 2019

Citation: Zhang Z, Dai X, Qi J, Ao Y, Yang C, Li Y. Effect of albumin administration on post-operation mortality, duration on ventilator, and hospital stay on patients in cardiac intensive care: An observational study. Trop J Pharm Res 2019; 18(6):1339-1345 doi: 10.4314/tjpr.v18i6.27

© 2019 The authors.
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Abstract

Purpose: To justify the use of albumin infusion in patients in post-surgery cardiac intensive care unit.

Methods: All patients who were hemodynamically stable before the operation and admitted into the surgical intensive care unit following coronary artery bypass, cardiopulmonary bypass, or aortic surgery, had no excessive postoperative bleeding and not on diuretic treatment, were included in the analysis. A total of 1998 patients were divided into two cohorts, viz, the first group was placed on albumin infusion (n = 999) while the second group received normal saline infusion (n = 999). Data were obtained from DICOM files of patients and records of pharmacy. Wilcoxon test or two-tailed paired t-test followed by Tukey post-hoc tests were performed for statistical analysis at 95 % of confidence level.

Results: Albumin and normal saline administration did not decrease the duration of mechanical ventilation, incidence of mechanical ventilation, need for blood transfusion, and length of hospital stay (p > 0.05). Albumin infusion decreased the need for fresh frozen plasma transfusion from 85 to 67, reduced mortality (p = 0.0005, q = 3.959), lowered serum lactate level (p < 0.0001, q = 43.853), but increased cardiac index (p < 0.0001, q = 12.192) as well as financial burden (p < 0.0001, q = 95.158) for the patients, compared to normal saline group.

Conclusion: In view of the foregoing, it is recommended that the use of restriction of albumin resuscitation in surgical intensive care unit should be restricted in this subset of patients evluated in this study.

Keywords: Artificial respiration, Cardiac surgical procedures, Intensive care unit, Mortality, Infusion, Serum albumin