Zun-Cheng Zheng 
,
Xiao-Yu Wang,
Xiao-Jing Du
For correspondence:- Zun-Cheng Zheng Email: zhengzc1967@gmail.com Tel:+865386298680
Received: 18 April 2015 Accepted: 2 September 2015 Published: 31 October 2015
Citation: Zheng Z, Wang X, Du X. Preparation and characterization of sustained release matrix tablets of tizanidine hydrochloride for spinal injuries. Trop J Pharm Res 2015; 14(10):1749-1754 doi: 10.4314/tjpr.v14i10.3
© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To formulate matrix type sustained-release (SR) tablets of tizanidine hydrochloride (TH) for prolonged drug release and improvement in motor activity after spinal injuries.
Methods: Matrix tablets were prepared by the wet granulation method using four polymers (hydroxyl propyl methyl cellulose [HPMC] K 100, ethyl cellulose [EC], guar gum, and polyvinylpyrrolidone (PVP K30) and characterized for hardness, friability, drug content, swelling, weight variation, in vitro drug release, and in vivo motor function activity using the spinal injury rat model.
Results: All tablets showed good drug content, hardness, and other physicochemical properties. The tablet formulations showed a percent drug release ranging from 92.54 ± 1.02 to 98.56 ± 1.26 % at the end of 12 h. Using the spinal injury rat model, negative control had a motor activity of only 12.75 %, while F4 (containing HPMC, EC, and PVP) and F5 (containing EC, guar gum, and PVP) had motor activities of 62.25% and 57.5%, respectively, compared with 68.0 % for normal controls.
Conclusion: SR matrix tablets of TH showed significant improvement in motor activity in post-traumatic spinal injury rat model.
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