Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-hyperglycemic effect of Vicia ervilia (L.) Willd (Fabaceae) seed extract and its effect on lipid profile, and hepatic and renal biomarkers in streptozotocin-induced diabetic rats

Derya Kartal, Necati Özok

Department of Biology, Faculty of Science, Van YÃ¼zÃ¼ncÃ¼ Yıl University, 65080, Tu#1;ba, Van, Turkey;

For correspondence:- Necati Özok Email: necatiozok@yyu.edu.tr Tel:+904322251051

Accepted: 19 August 2019 Published: 01 October 2019

Citation: Kartal D, Özok N. Anti-hyperglycemic effect of Vicia ervilia (L.) Willd (Fabaceae) seed extract and its effect on lipid profile, and hepatic and renal biomarkers in streptozotocin-induced diabetic rats. Trop J Pharm Res 2019; 18(9):1881-1887 doi: 10.4314/tjpr.v18i9.14

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the impact of Vicia ervilia (L.) Willd (Fabaceae) lyophilized extract on various biomarkers of streptozotocin-induced diabetic rats.

Methods: Adult male rats (36) were divided into 6 groups, viz, normal control (NC), diabetes control (DC), and treatment groups. Experimental diabetes was induced with streptozotocin. Blood samples were taken from the tail veins daily for 25 days. Fasting and postprandial blood glucose levels of rats were determined. The rats were sacrificed and blood, kidney and liver were taken for biochemical analysis.

Results: Blood glucose decreased in DC groups compared to NC group (p ≤ 0.05). In diabetic extract groups, glycated Hb decreased compared to DC group (p ≤ 0.05). Alpha glucosidase activity was reduced in all treatment groups compared to DC group (p ≤ 0.05). Only triglyceride levels of diabetes extract (400 mg/mL) group decreased compared to DC (p ≤ 0.05). Total cholesterol levels fell compared to NC and DC groups (p ≤ 0.05). Low density lipoprotein was lower compared to NC (p ≤ 0.05), while aspartate aminotransferase and alanine aminotransferase levels rose in diabetic extract groups compared to NC, but fell in some diabetic extract groups compared to DC group (p ≤ 0.05). Lactate dehydrogenase decreased in all diabetic extract groups compared to NC and DC (p ≤ 0.05). Serum urea and creatinine levels were higher in diabetic extract groups compared to NC, but decreased in DC group (p ≤ 0.05).

Conclusion: These findings demonstrate that Vicia ervilia lyophilized extract haas positive effects on blood glucose and biochemical parameters in diabetic rats compared to DC of V. ervilia seed extract.

Keywords: Antidiabetic, Diabetes mellitus, Lipid profile, Diabetic nephropathy, Liver damage, Streptozotocin, Vicia ervilia