Gihyun Lee1,
Kang-Hyun Leem2,
Wonnam Kim2 
For correspondence:- Wonnam Kim Email: wonnam_kim@semyung.ac.kr Tel:+82436491697
Accepted: 22 October 2019 Published: 30 November 2019
Citation: Lee G, Leem K, Kim W. Recent perspectives on chemosensitizing effects of Astragalus membranaceus-derived components: A mini review. Trop J Pharm Res 2019; 18(11):2455-2460 doi: 10.4314/tjpr.v18i11.32
© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
The dried root of Astragalus membranaceus (Fisch.) Bge (AM) is commonly used in herbal medicine in Korea, Japan and China. The traditional use of AM is to invigorate the Qi as a potential treatment for fatigue, loss of appetite, diarrhea, and anemia. Recent studies have expanded current understanding of AM as an antidiabetic, antioxidant, anti-inflammatory, antihyperlipidemic and anticancer agent. Active compounds derived from AM, including polysaccharides, saponins and flavonoids, appear to act as potent chemosensitizers when combined with conventional anticancer agents. Chemosensitizers represent a promising approach for enhancing anticancer efficacy and reversing multidrug resistance. This review highlights the chemosensitizing activity and related molecular mechanisms of components isolated from AM.
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