Yi-Kuan Gao1,2,
Cheng-Jia Gui1,2,
Wen-Qiang Xin1,
Dan Hu2,
Xin-Yu Yang1 
For correspondence:- Xin-Yu Yang Email: yangxinyu@tmu.edu.cn
Accepted: 23 November 2019 Published: 31 December 2019
Citation: Gao Y, Gui C, Xin W, Hu D, Yang X. Assessment of mild hypothermia combined with edaravone for the treatment of severe craniocerebral injury. Trop J Pharm Res 2019; 18(12):2557-2562 doi: 10.4314/tjpr.v18i12.14
© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To study the clinical effect of combining mild hypothermia with edaravone in the treatment of severe craniocerebral injury.
Methods: One hundred and twenty (120) patients with severe craniocerebral injury who were admitted to Tianjin Medical University General Hospital were assigned to control and study groups, respectively. Patients in the control group were given conventional treatment while those in the study group received combined treatment of mild hypothermia and edaravone, in addition to the conventional treatment received by control group. Clinical efficacy and prognosis were compared between the two groups.
Results: The intracranial pressure (ICP) of both groups decreased after admission, but the decrease in ICP was more pronounced in the study group at various time points (p < 0.05). Blood lactic acid levels decreased in both groups after admission, while brain-derived neurotrophic factor (BDNF) levels increased. Improvement in blood lactic acid and BDNF was greater in the study group than in control group (p < 0.05). The treatment resulted in significant decrease in residual hematoma volume and edema range in the study group, relative to control (p < 0.05). There was a decrease in National Institutes of Health Stroke Scale (NIHSS) scores, and increase in Glasgow outcome scale (GOS) scores in both groups. However, improvement in NIHSS and GOS scores in the study group was superior to those in control group (p < 0.05).
Conclusion: Mild hypothermia in combination with edaravone exerts a beneficial clinical effect in severe craniocerebral injury. The combined treatment rapidly reduces ICP and range of encephaledema, improves cerebral blood supply, promotes absorption of intracranial hematoma, and relieves nervous dysfunction.
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