Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Novel sulfamoylamino-containing cephalosporin derivatives, and their in vitro antibacterial properties

Xudong Jiang¹, Li Chen¹, Xiaoling Lu^1,2 , Lan Liao¹, WeiGuang Wang¹, Xiaocheng Huang²

¹School of Medicine, Guangxi University of Science and Technology; ²College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545005, China.

For correspondence:- Xiaoling Lu Email: v0964y@163.com

Accepted: 28 November 2019 Published: 31 December 2019

Citation: Jiang X, Chen L, Lu X, Liao L, Wang W, Huang X. Novel sulfamoylamino-containing cephalosporin derivatives, and their in vitro antibacterial properties. Trop J Pharm Res 2019; 18(12):2617-2621 doi: 10.4314/tjpr.v18i12.22

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To prepare and develop new antibacterial agents with novel molecular structures.

Method: A series of novel sulfamoylamino-containing cephalosporin derivatives were synthesized. The in vitro antibacterial effects of the derivatives against Gram-positive bacteria (S. aureus, S. pneumonia and S. epidermidis), and Gram-negative bacteria (E. coli, P. aeruginosa, and K. pneumonia) were investigated.

Results: Compounds 13a and 13b exhibited excellent antibacterial effects against all the Gram-positive and Gram-negative bacteria tested, when compared with other cephalosporin derivatives.

Conclusion: Of these new cephalosporin derivatives, compounds 13a and 13b show the most potent antibacterial activity and would need to be further investigated.

Keywords: Cephalosporin, Sulfamoylamino derivatives, Gram-positive, Gram-negative, Antibacterial