Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of Pluronic F-127 gel containing green tea catechin extract on chronic periodontitis - A clinical study

Raghavendra Reddy Nagate¹, M Yuvaraja², Saad M AlQahtani¹ , Nabeeh A AlQahtani¹, Shreyas Tikare¹, Shankar T Gokhale¹, K S Ravi¹, Mohammed Fadul A Elagib¹

¹Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha â€“ 62529, Saudi Arabia; ²Department of Periodontics, Vinayaka Missionâ€™s Shankarachariyar Dental Sciences, Salem â€“ 636308, India.

For correspondence:- Saad AlQahtani Email: rnagati@kku.edu.sa

Accepted: 20 January 2020 Published: 29 February 2020

Citation: Nagate RR, Yuvaraja M, AlQahtani SM, AlQahtani NA, Tikare S, Gokhale ST, et al. Efficacy of Pluronic F-127 gel containing green tea catechin extract on chronic periodontitis - A clinical study. Trop J Pharm Res 2020; 19(2):427-432 doi: 10.4314/tjpr.v19i2.27

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the efficacy of pluronic F-127 gel containing green tea catechin extract as a local drug delivery system in the treatment of chronic periodontitis.

Methods: A total of 20 chronic periodontitis patients participated as per the set inclusion and exclusion criteria. Complete scaling and root planing (SRP) was done for all subjects and pluronic F-127 gel containing green tea catechin was applied on one site. The contralateral site received SRP alone. The plaque index (PI), gingival index (GI), and probing pocket depth (PPD) were recorded at baseline and on the 28th day.

Results: At the 28th-day follow-up, green tea catechin tooth sites showed significantly lower mean scores (GI = 0.55, p = 0.30 and PPD = 3.35 mm) than the corresponding SRP tooth sites (GI = 1.25, PI = 1.15, and PPD = 4.40 mm) (p < 0.05).

Conclusion: When compared to scaling and root planing alone, the local drug delivery gel containing green tea catechin as an adjuvant was more effective in reducing the clinical parameters of periodontitis.

Keywords: Adjuvant therapy, Camellia sinensis, Local drug delivery, Periodontal pocket