Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of intrapleural injection of erythromycin on congenital refractory chylothorax in the newborn

Yun Shi, Ying Zhang

Department of Pediatrics, Heji Hospital Affiliated with Changzhi Medical College, Changzhi Shanxi 046000, China;

For correspondence:- Ying Zhang Email: zhangyingmedcine@sina.com

Accepted: 24 June 2020 Published: 31 July 2020

Citation: Shi Y, Zhang Y. Effect of intrapleural injection of erythromycin on congenital refractory chylothorax in the newborn. Trop J Pharm Res 2020; 19(7):1519-1523 doi: 10.4314/tjpr.v19i7.26

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the therapeutic effect of intrapleural injection of erythromycin on congenital refractory chylothorax in the newborn, in order to provide a more efficient approach for its treatment.

Methods: A retrospective study was conducted with 13 cases of congenital chylothorax in newborns that received conventional treatment and intrapleural injection of erythromycin.

Results: A total of 10 out of 13 child patients (76.9 %) received active treatment. Furthermore, the patients who received the intrapleural injection of erythromycin were administered the injection a total of 1 - 3 times (1.5 ± 0.6) on the average with the dose ranging from 80 – 210 mg (mean, 126.5 ± 32.7 mg). Thereafter, they received continuous drainage for 7 – 12 days (mean time, 10.2 d). Drainage volume ranged from 50 - 150ml (mean, 84.3 ± 35.2 mL). Patients that did not receive the erythromycin treatment received continuous drainage for 5 – 13 d (mean, 8.6 day), with the drainage volume ranging from 67 - 132 mL (mean, 92.3 ± 25.6 mL).

Conclusion: Therefore, intrapleural injection of erythromycin has a certain therapeutic effect on congenital refractory chylothorax in the newborn.

Keywords: Erythromycin intrapleural injection, Congenital refractory chylothorax, Newborn