Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Oxidative degradation of some antibiotics by permanganate ion in alkaline medium: A kinetic and mechanistic approach

Ahmed Fawzy^1,2 , Metwally Abdallah^1,3, Nada Alqarni^1,4

¹Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; ²Chemistry Department, Faculty of Science, Assiut University, Assiut; ³Chemistry Department, Faculty of Science, Benha University, Benha, Egypt; ⁴Chemistry Department, Faculty of Science, Bisha University, Bisha, Saudi Arabia.

For correspondence:- Ahmed Fawzy Email: afsaad13@yahoo.com Tel:+966590994316

Accepted: 17 August 2020 Published: 30 September 2020

Citation: Fawzy A, Abdallah M, Alqarni N. Oxidative degradation of some antibiotics by permanganate ion in alkaline medium: A kinetic and mechanistic approach. Trop J Pharm Res 2020; 19(9):1999-2007 doi: 10.4314/tjpr.v19i9.28

© 2020 The authors.
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Abstract

Purpose: To investigate the kinetics of oxidative removal of two β-lactam antibiotics (A), namely, ampicillin and flucloxacillin.

Methods: In this study, permanganate ion (MnO₄^-) was used as an oxidant in an alkaline medium at fixed ionic strength of 0.1 mol dm^-3 and a temperature of 298 K utilizing a spectrophotometric technique. The obtained oxidation products were characterized using spot tests and FT-IR spectra.

Results: The stoichiometry of the reactions was 1:4 (A : MnO₄^-). The reactions were a first order credence in [MnO₄^-] and fractional-first order kinetics in antibiotic and hydroxyl ion. Influence of ionic strength was successfully explored. Dependence of reaction rates on temperature was studied and the activation parameters were computed and discussed. A plausible mechanism for the oxidation reactions has been elucidated. A consistent rate-law expression was also derived.

Conclusion: This study introduces a significant treatment method for antibiotic removal, thus helping to protect the environment and human health.

Keywords: Permanganate, Antibiotics, Oxidative degradation, Kinetics, Mechanism