Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Relationship between integrin αvβ3 and αvβ1 expression levels and clinicopathological characteristics of cervical cancer

Feng Xiumei¹, Jin Li²

¹Gynecology Department, Jingmen No.2 People's Hospital, Hubei Jingmen 448000, China; ²Department, Jingmen No.1 People's Hospital, Hubei Jingmen 448000, China.

For correspondence:- Jin Li Email: hg98714@126.com Tel:+8617715423692

Accepted: 2 May 2020 Published: 30 November 2020

Citation: Xiumei F, Li J. Relationship between integrin αvβ3 and αvβ1 expression levels and clinicopathological characteristics of cervical cancer. Trop J Pharm Res 2020; 19(11):2323-2328 doi: 10.4314/tjpr.v19i11.11

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: The study was aimed at investigating the relationship between integrin ανβ3 and ανβ1 expression levels and clinicopathological characteristics of cervical cancer.

Methods: A total of 78 cases of pathologically confirmed cervical cancer patients admitted to our hospital from April 2012 to September 2013 were selected. The expression levels of integrin ανβ3 and ανβ1 in the cervical cancer tissue (study group, n=78) and adjacent normal tissue (control group, n=49) were detected by immunohistochemistry. Then, the relationship between the expression of two indicators in cervical cancer tissues and the clinicopathological features of patients were analyzed.

Results: Positive expression rate of integrin ανβ3 in cervical cancer tissues was significantly higher than that in adjacent normal tissues (73.08% vs 2.04%, P<0.05). For integrin α6β1, the positive expression rate in cervical cancer tissues was significantly higher than that in adjacent normal tissues (67.95% vs 8.16%, P<0.05). The expression level of integrin ανβ3 in cervical cancer tissues with different degree of differentiation, tumor diameter, depth of invasion, and lymph node metastasis was significantly different (P<0.05). Integrin ανβ1, the expressed in cervical cancer tissues with significantly different degrees of differentiation, infiltration depth and lymph node metastasis (P<0.05).

Conclusion: The integrin ανβ3 and ανβ1 are highly expressed in cervical cancer tissue. The expression level of integrin ανβ3 was related to the differentiation degree, diameter of tumor, infiltration depth and lymph node metastasis, while the expression of integrin ανβ1 was related to the clinicopathological features, such as the differentiation degree of cancer tissues, depth of invasion, and lymph node metastasis.

Keywords: Cervical cancer, Clinicopathological characteristics, Integrin αvβ1, Integrin αvβ3.