Xiaoping Yang1,
Danjie Zhang1,
Deling Kong2,
Jin Zhang1,
Bingwen Dang3 
1Department of Thoracic Surgery;
2Department of Nursing, The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, Shaanxi 710009;
3Department of Anesthesiology, Yulin No. 2 Hospital, Yulin, Shaanxi 719000, China.
For correspondence:- Bingwen Dang
Email: 43056862@qq.com Tel:+869123362001
Accepted: 12 November 2020
Published: 31 December 2020
Citation:
Yang X, Zhang D, Kong D, Zhang J, Dang B.
Comparison of efficacy and safety profiles of epidural analgesia and opioid analgesia in Chinese patients with thoracic trauma: A preliminary report. Trop J Pharm Res 2020; 19(12):2683-2689
doi:
10.4314/tjpr.v19i12.29
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Abstract
Purpose: To compare the efficacy and safety profiles of epidural analgesia (EA) and opioid analgesia (OA) in Chinese patients with thoracic trauma (TT).
Methods: Patients with confirmed diagnosis of thoracic trauma were given either EA (via a catheter) or slow-release OA. The following efficacy variables were assessed in the two treatment groups: pain score, and changes in cytokine and catecholamine levels from baseline after treatment. Moreover, respiratory parameters were determined before and after treatment. The safety associated with each anesthesia was also evaluated. Quantitative data were analyzed either with Student’s t-test or Mann-Whitney test, while categorical data were analyzed using Fisher exact or Chi-square test, based on data size.
Results: A total of 200 patients completed the study (100 patients in each group). Pain, as assessed by verbal rating scale (VRS), was slightly lower in patients after treatment with EA, when compared to the patients treated with OA. However, the difference was not statistically significant (p < 0.05). Maximum inspiratory force (cmH2O) and tidal volume (liters) were slightly improved in patients treated with EA, when compared to OA-treated patients, although the difference was not statistically significant (p < 0.05). Moreover, the two treatments produced comparable levels of cytokines and catecholamines.
Conclusion: The efficacy and safety data for EA and OA in Chinese non-obese patients with TT indicate numerically favorable outcome for EA, when compared to OA.
Keywords: Epidural analgesia, Opioid analgesia, Chinese patients, Thoracic trauma
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