Xin-Yun Zhang1,
Jian-Rong Zhao2,
Yi-Le Xue3,
Ying-Kui Jiang1,
Wei-Min Jiang1 
1Department of Infection, Huashan Hospital Affiliated to Fudan University, Shanghai 200040;
2Department of Medicine, Infectious Disease Hospital in Yunnan Province, Kunming 100142;
3Department of AIDS, Sexually Transmitted Diseases, Shanghai Municipal Center for Disease Control & Prevention, Shanghai 200336, China.
For correspondence:- Wei-Min Jiang
Email: jiang7514@gmail.com Tel:+862152887953
Received: 5 January 2015
Accepted: 2 November 2015
Published: 27 December 2015
Citation:
Zhang X, Zhao J, Xue Y, Jiang Y, Jiang W.
Role of CD5-negative CD8+ T cells in adaptation to antigenic variation of human immunodeficiency virus type 1. Trop J Pharm Res 2015; 14(12):2207-2212
doi:
10.4314/tjpr.v14i12.8
© 2015 The authors.
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Abstract
Purpose: To investigate the effect of 3-oxotirucalla-7, 24-dien-21-oic acid on CD8+ T cell recovery in human immunodeficiency virus type 1 (HIV-1) disease.
Methods: The increase in the rates of CD8+ T cells over 48 weeks following treatment with 3-oxotirucalla-7, 24-dien-21-oic acid was investigated. Plasma HIV-1 load was measured by Versant™ HIV-1 RNA 3.0 branched chain DNA assay while flow cytometry was used for blood CD4 cell counts. For the analysis of the data obtained, Stata version 9.0 was employed.
Results: 3-Oxotirucalla-7, 24-dien-21-oic acid treatment increased CD8+ T cell count from a median of 89 % at baseline to 99 % at 48 weeks. The proportion of patients with CD8+ T cell count < 90 % decreased from 50 % at baseline to 1 %. There was a similar rate of phase 1 CD8+ T cell recovery and greater rates of phase 2 recovery in patients with baseline CD8+ T counts < 50 cells/μL. Among those that achieved CD8+ T cell count > 500 cells/μL at 48 weeks, 23 % had baseline CD8+ T cell counts of < 50 cells/μL. However, the proportion of the patients that attained CD8+ T count of 200 cells/μL at 48 weeks was lower than those with higher baseline CD4 cell counts.
Conclusion: 3-Oxotirucalla-7,24-dien-21-oic acid treatment induces greater tendency for CD8+ T cell recovery in patients with baseline CD8+ T cell counts < 50 cells/μL during 48 weeks of treatment. Therefore, 3-oxotirucalla-7,24-dien-21-oic acid is a promising agent for CD8+ T cell count recovery in patients with HIV infection.
Keywords: CD8+ T cells, HIV infection, Oleanolic acid, Lymphocyte cell, Cell recovery
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