Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Antidiabetic effects of ethanol extract of Uromastyx hardwickii Smith (Agamidae) skin on streptozotocin-induced diabetes mellitus in mice

Waqas A Shams¹, Samuel O Onoja² , Gauher Rehman¹, Saif U Islam¹, Khurshaid Khan¹, Muhmmad Ibrar¹, Saima B Sia¹, Saba G Ayaz¹, Sajid Ali³, Muhammad Israr¹, Aziz ullah¹, Dawood Safi¹

¹Department of Zoology, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa 23200, Pakistan; ²Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, PMB 7267, Umuahia, Abia State, Nigeria; ³Department of Chemistry, University of Malaknd, Khyber Pakhtunkhwa 18800, Pakistan.

For correspondence:- Samuel Onoja Email: onoja.samuel@mouau.edu.ng Tel:+2348030613032

Accepted: 19 February 2021 Published: 31 March 2021

Citation: Shams WA, Onoja SO, Rehman G, Islam SU, Khan K, Ibrar M, et al. Antidiabetic effects of ethanol extract of Uromastyx hardwickii Smith (Agamidae) skin on streptozotocin-induced diabetes mellitus in mice. Trop J Pharm Res 2021; 20(3):627-632 doi: 10.4314/tjpr.v20i3.27

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the in vivo hypoglycemic potential of the ethanol extract of Uromastyx hardwickii skin (EEUHS).

Methods: Streptozotocin-induced diabetic mice received graded doses (100 and 200 mg/kg) of EEUHS for oral glucose tolerance and hypoglycemic test. The effects of EEUHS on body weight gain, urea, creatinine, cholesterol and hemoglobin concentration were also investigated.

Result: The blood glucose concentrations of the EEUHS-treated groups were diminished (p < 0.05) relative to the diabetic control group. The urea, creatinine and cholesterol levels of the EEUHS-treated groups were lower (p < 0.05), but their hemoglobin concentrations were higher (p < 0.05) relative to the diabetic control group.

Conclusion: The EEUHS elicits hypoglycemic effects and ameliorates complications of diabetes mellitus in streptozotocin-induced diabetic mice. This suggests that EEUHS can potentially be developed for the management of diabetic patients.

Keywords: Anemia, Antidiabetic, Lizard, Glibenclamide, Streptozotocin, Uromastyx hardwickii, Weight loss