Ling Chen,
Wei Deng,
Shirong Liu,
Fengchao Li,
Huimin Li,
Guihua Jiang 
For correspondence:- Guihua Jiang Email: 11469413@qq.com
Accepted: 20 March 2021 Published: 30 April 2021
Citation: Chen L, Deng W, Liu S, Li F, Li H, Jiang G. Spectrum-effect relationship between serum HPLC fingerprints and activation of blood circulation and removal of blood stasis by Chuanxiong. Trop J Pharm Res 2021; 20(4):757-765 doi: 10.4314/tjpr.v20i4.14
© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To study the active ingredients of Chuanxiong (CX) in promoting blood circulation and removing blood stasis.
Methods: Blood-activating effects and serum HPLC fingerprints of CX extracts from different parts of China were studied and the spectrum-effect relationship between them was established by grey correlation analysis.
Results: After treatment with CX extracted using different solvents, hemorheology indices were lower than those in the model group, and the effect of dichloromethane was better than that of other solvents (p < 0.05 or p < 0.01). There were 6 common peaks by fingerprint analysis. Peaks 1 - 5 were identified as senkyunolide I, senkyunolide H, senkyunolide A, coniferyl ferulate and ligustilide, respectively.
Conclusion: Analysis of the spectrum–effect relationship indicates the contribution of the five components to the blood-activating effect of CX. The findings lend some scientific justification for using CX to remove blood stasis, and selection of quality evaluation indices for CX.
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